A native of Long Island, New York, Vince Carey started his professional career at the National Bureau of Economic Research after taking a B.A. in Philosophy in 1982 with an Honors Thesis entitled “Verificationism and Private Language”. After contributing to the computations underlying the volume “What Do Unions Do” by Freeman and Medoff, Vince took a job at the Channing Lab with Alvaro Munoz, Bernie Rosner, Ira Tager, and Scott Weiss, working primarily on effects of passive smoking in children, and building the foundations of on-premises computing at the Lab. With the onset of the AIDS epidemic, Vince followed Munoz to Johns Hopkins to work on the Multicenter AIDS Cohort Study, contributing to methods for longitudinal data analysis and the analysis of prevalent cohorts. His Ph.D. thesis addresses analysis of large binary clusters with complex dependence structure. The alternating logistic regression algorithm developed in this work was applied in research on epilepsy and international epidemiology. Vince returned to the Channing Lab in 1993, contributing to research on obesity and anthropometry in the Nurses’ Health Study, interpretation of anthropometry in pediatric HIV clinical trials, and the design and analysis of clinical trials of nutritional interventions. Vince now leads the technical core of the Bioconductor project, a global open source, open development project for software useful for genome-scale data science.