Dr. Holmes is a professor of medicine at Harvard Medical School. Her research interests include lifestyle factors (diet, weight change, physical activity, and psychosocial factors, common medications like aspirin) affecting quality of life and survival after a cancer diagnosis, as well as the association between diet and breast cancer risk. Other research interests include diet and lifestyle influences on endogenous levels of steroid hormones and insulin-like growth factors, and ethnic differences in obesity and other lifestyle factors affecting chronic disease risk. She co-edited a book on nutrition for cancer survivors published by the American Cancer Society. She has worked with the Nurses’ Health Study since 1997. Since 2007 she has helped to design a collaborative longitudinal study of non-communicable disease (obesity, diabetes, high blood pressure, heart disease, cancer) at 5 sites in sub-Saharan Africa, called the Africa / Harvard School of Public Health Partnership for Cohort Research and Training (PaCT). Since 2015 she was the co-Principal Investigator of the Aspirin for Breast Cancer Trial, testing whether treating breast cancer patients with aspirin will prevent their breast cancer from recurring. She also serves as the Senior Mentor for Diversity, Equity, and Inclusion for the Channing Division of Network Medicine.